Folic Acid Preventing Breast Cancer La Plata MD

The article is about the benefits of folic acid, particulary in preventing breast cancer.

Krishan Murari Mathur, MD
(301) 843-6040
PO Box 2729
La Plata, MD
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Oncology (Cancer)
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Male
Education
Medical School: S M S Med Coll, Univ Of Rajasthan, Jaipur, Rajasthan, India
Graduation Year: 1977

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M Ashraf Meelu, MD
(301) 638-1007
10 Saint Patricks Dr Ste 408
Waldorf, MD
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Oncology (Cancer)
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Male
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Panjabi, Urdu
Education
Medical School: Punjab Med Coll, Univ Of Punjab, Faisalabad, Pakistan
Graduation Year: 1980
Hospital
Hospital: St Marys Hospital, Leonardtown, Md; Southern Maryland Hospital, Clinton, Md; Calvert Mem Hosp, Prnc Frederck, Md; Civista Med Ctr, La Plata, Md; Ft Washington Med Ctr, Ft Washington, Md
Group Practice: Southern Maryland Oncology

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Boris Naydich, MD
(301) 705-5802
11340 Pembrooke Sq Ste 201
Waldorf, MD
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Oncology (Cancer), Radiation Oncology
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Medical School: Kemerovskij Med Inst, Kemerovo, Russia
Graduation Year: 1973

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Ashima Saini, MD
(414) 352-3100
30077 Business Center Dr
Charlotte Hall, MD
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Medical School: Univ Of Md Sch Of Med, Baltimore Md 21201
Graduation Year: 1986

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Oliver Alabaster, MD
Alexandria, VA
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Medical School: Charing Cross And Westminster Med Sch, London (352-07 Pr 01/71)
Graduation Year: 1966

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Krishan Mathu, MD
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3500 Old Washington Rd Ste 102
Waldorf, MD
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Graduation Year: 2007

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Ashima Saini
(301) 705-5802
11340 Pembrooke Sq
Waldorf, MD
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Karen Jane Hoffmeister, DO
Waldorf, MD
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Oncology (Cancer)
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Medical School: Philadelphia Coll Of Osteo Med, Philadelphia Pa 19131
Graduation Year: 1984

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Sarah A Leonhard
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13605 Baden Westwood Road
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Laxmi Narain Berwa
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Folic Acid Preventing Breast Cancer

High Intake of Folate May Be Protective Against Breast Cancer.
Date: Tuesday, October 20, 2009
Source: American Journal of Clinical Nutrition
Related Monographs: Breast Cancer, Folic Acid




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Breast cancer is a physically and emotionally traumatizing disease. Unfortunately, the incidence of breast cancer has been increasing steadily for decades. In 1972 when President Nixon declared our national war on cancer, a woman's lifetime risk of developing breast cancer was 1 in 20. Today breast cancer rates have escalated to the point where women's lifetime risk of developing breast cancer is 1 in 8. In the year 2007, the American Cancer Society estimated that nearly 240,510 women would be diagnosed with breast cancer and approximately 40,460 women would die from it. This means that approximately every two and a half minutes a woman in the United States is diagnosed with breast cancer and that approximately every thirteen minutes, a woman dies from this disease. Breast cancer has become the second largest cause of cancer death in women, after lung cancer, and the leading cause of death for women between the ages of 35 and 54.


Folic acid (also known as folate) is a member of the water-soluble B vitamin group. Isolated in 1946 from spinach leaves, its name comes from folium, the Latin word for leaf. In the body, folic acid is converted to a more biologically active form. Folate has many clinical applications such as: Alzheimer's disease, alcoholism, atherosclerosis, birth defects, cervical dysplasia, cognitive enhancement, depression, gingivitis, pregnancy and lactation. Folic acid is one of the most common vitamin deficiencies. Substantial destruction occurs during food processing and heat, light, and oxygen easily destroy it. Symptoms of folic acid deficiency include headache, fatigue, hair loss, insomnia, birth defects, cervical dysplasia, and elevated homocysteine.


A study published in the American Journal of Clinical Nutrition has found that very high folate intake may be protective against breast cancer. The trial included 35,023 women aged 50-76 years who participated in the Vitamins and Lifestyle (VITAL) cohort study. It was determined that between the years 2000 to 2006 a total of 743 women were diagnosed with invasive breast cancer. The researchers found that women who consumed 1,272 or more dietary folate equivalents (DFE)/day of total folate over an average 10-year period had a 22 percent decrease in breast cancer risk compared with women consuming 345 DFE/day or less. It was also discovered that the effect of very high folate intake was more pronounced when focusing on estrogen receptor (ER)-negative tumors alone, which is particularly important since ER-negative breast cancers generally have a poorer prognosis than their ER-positive counterparts. This research appears to indicate that high intakes of folate may actually be protective against breast cancer, especially ER-negative tumors.1


1 Maruti SS, Ulrich CM, White E. Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr. 2009;89(2):624-33.



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