Fungal Infection Treatments Salisbury MD

A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections in Salisbury.

Johnson-McKee Animal Hospital
(410) 749-9422
404 Snow Hill Rd
Salisbury, MD

Data Provided by:
Chesapeake Chiropractic
(410) 334-2233
706 Camden Ave
Salisbury, MD

Data Provided by:
Franklyn William Colligan, MD
(410) 242-2000
Salisbury, MD
Specialties
General Practice
Gender
Male
Education
Medical School: Univ Of Md Sch Of Med, Baltimore Md 21201
Graduation Year: 1968

Data Provided by:
Clark H Willis
(410) 543-7100
100 E Carroll St
Salisbury, MD
Specialty
Family Practice, Emergency Medicine

Data Provided by:
Kathleen A DeVine
(410) 543-7100
100 East Carroll Street
Salisbury, MD
Specialty
Internal Medicine, Emergency Medicine

Data Provided by:
Wicomico Veterinary Hospital
(410) 742-7543
207 Executive Plz
Salisbury , MD

Data Provided by:
Helen M Baldado
(410) 742-0871
547 Riverside Drive
Salisbury, MD
Specialty
Internal Medicine, Hematology

Data Provided by:
Robert John Branton
(410) 546-5141
1205 Pemberton Dr
Salisbury, MD
Specialty
Internal Medicine

Data Provided by:
Lorraine Fay Jarrah
(410) 546-5141
1205 Pemberton Dr
Salisbury, MD
Specialty
Internal Medicine

Data Provided by:
Inja Joe Hwang, MD
(410) 543-4000
Salisbury, MD
Specialties
General Practice
Gender
Female
Education
Medical School: Ewha Women'S Univ, Coll Of Med, Seoul, So Korea
Graduation Year: 1969

Data Provided by:
Data Provided by:

Fungal Infection Treatments

Provided By:

A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections, new research has found.

University of Rochester Medical Center researchers found that tamoxifen kills yeast in mice with Candida infections, which can be fatal to people with compromised immune systems, including people with cancer or HIV and those taking immunosuppressants for chronic conditions.

At extremely high levels, tamoxifen slashed yeast levels by 150-fold, causing most fungus cells to break up and die while halting surviving cells from progressing into a disease-causing state, their study found.

"It's still early, but if tamoxifen, or molecules like it, turns out to be an effective treatment against serious fungal infections, it'll be a welcome addition to our arsenal," Dr. Damian Krysan, an assistant professor of pediatrics at the university and an author of the study, said in a university news release.

The results are published in the August issue of Antimicrobial Agents and Chemotherapy.

Available antifungal medications pose some issues for people who need them the most, according to background information in the news release. The only new class of antifungals approved for use in the past two decades is generally effective, but they can only be taken intravenously, which poses logistic and other problems for some patients. And the most common oral antifungal medication only slows fungus cell growth, making it difficult for immune-compromised patients to completely shake their infections.

"We don't have vaccines against fungal infections, and the few drugs we do have aren't always effective," Krysan said. "We've got a lot more work to do to figure out whether tamoxifen could be used in high doses or whether it could be used in combination with other treatments, but we're excited about the possibility of giving doctors another way to help these critically ill patients."

More information

The U.S. Centers for Disease Control and Prevention has more about Candidiasis.

SOURCE: University of Rochester Medical Center, news release, July 20, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com