Hormone Therapy for Lung Cancer Alexandria VA

Taking a combination form of hormone replacement therapy, which includes both estrogen and progestin, increases a woman's risk for dying from lung cancer, a new study has found. The finding stems from an analysis of data from the Women's Health Initiative trial on 16,608 postmenopausal women, aged 50 to 79, in the United States who had been randomly assigned to take either a once-daily tablet of 0.625 milligrams conjugated equine estrogen plus 2.5 mg medroxyprogesterone acetate or a placebo.

Inova Alexandria Hospital
(703) 504-3000
4320 SEminary Road
Alexandria, VA
specialty
General medical surgical
Hospital Type
Nongovernment, Not-for-profit
Hospital System
Inova Health System

Data Provided by:
Inova Mount Vernon Hospital
(703) 664-7000
2501 Parker's Lane
Alexandria, VA
specialty
General medical surgical
Hospital Type
Nongovernment, Not-for-profit
Hospital System
Inova Health System

Data Provided by:
Specialty Hosps Of Washington
(202) 574-5700
4601 Martin Luther King Jr Ave
Washington, DC
specialty
Long-Term Acute Care
Hospital Type
Investor-owned (for profit)
Hospital System
Specialty Hospitals of America

Data Provided by:
Virginia Hospital Center
(703) 558-5000
1701 North George Mason Drive
Arlington, VA
specialty
General medical surgical
Hospital Type
Nongovernment, Not-for-profit

Data Provided by:
Inova Fairfax Hospital
(703) 776-4001
3300 Gallows Road
Falls Church, VA
specialty
General medical surgical
Hospital Type
Nongovernment, Not-for-profit
Hospital System
Inova Health System

Data Provided by:
Northern Virginia Comm Hosp
(703) 671-1200
601 South Carlin Springs Road
Arlington, VA
specialty
General medical surgical
Hospital Type
Investor-owned (for profit)
Hospital System
HCA

Data Provided by:
Dominion Hospital
(703) 536-2000
2960 Sleepy Hollow Road
Falls Church, VA
specialty
Psychiatric
Hospital Type
Investor-owned (for profit)
Hospital System
HCA

Data Provided by:
Greater Southeast Comm Hosp
(202) 574-6000
1310 Southern Avenue SE
Washington, DC
specialty
General medical surgical
Hospital Type
Investor-owned (for profit)
Hospital System
Envision Hospital Corporation

Data Provided by:
St Elizabeths Hospital
(202) 562-4000
2700 Martin L King Jr Ave SE
Washington, DC
specialty
Psychiatric
Hospital Type
Government, Nonfederal

Data Provided by:
Capital Hospice
(703) 538-2065
6565 Arlington Boulevard
Falls Church, VA
specialty
Other specialty
Hospital Type
Nongovernment, Not-for-profit

Data Provided by:
Data Provided by:

Hormone Therapy for Lung Cancer

Provided By:

SATURDAY, Sept. 19 (HealthDay News) -- Taking a combination form of hormone replacement therapy, which includes both estrogen and progestin, increases a woman's risk for dying from lung cancer, a new study has found.

The finding stems from an analysis of data from the Women's Health Initiative trial on 16,608 postmenopausal women, aged 50 to 79, in the United States who had been randomly assigned to take either a once-daily tablet of 0.625 milligrams conjugated equine estrogen plus 2.5 mg medroxyprogesterone acetate or a placebo.

After eight years, 73 women taking the hormone therapy and 40 women in the placebo group had died of lung cancer. That meant, according to the researchers, that women who took the drug were 71 percent more likely to die from the disease.

The study also found that women taking the hormone therapy were 28 percent more likely to be diagnosed with lung cancer, although the study noted that the finding was not statistically significant.

"Treatment with estrogen plus progestin in postmenopausal women ... increased the number of deaths from lung cancer, in particular deaths from non-small-cell lung cancer," concluded Rowan Chlebowski, of the Los Angeles Biomedical Research Institute at Harbour-UCLA Medical Center, and his colleagues.

The researchers urged that the findings "be incorporated into risk-benefit discussions with women considering combined hormone therapy, especially those with a high risk of lung cancer ... such as current smokers or long-term past smokers."

Dr. Apar Kishor Ganti, from the University of Nebraska Medical Center in Omaha, wrote in an accompanying editorial that "because the optimum safe duration of hormone-replacement therapy in terms of lung cancer survival is unclear, such therapy should probably be avoided in women at a high risk of developing lung cancer, especially those with a history of smoking."

In fact, Ganti questioned whether hormone therapy should be used at all.

"These results, along with the findings showing no protection against coronary heart disease, seriously question whether hormone-replacement therapy has any role in medicine today," he wrote. "It is difficult to presume that the benefits of routine use of such therapy for menopausal symptoms outweigh the increased risks of mortality, especially in the absence of improvement in the quality of life."

The study, which appears online and in an upcoming print issue of The Lancet, was released Sept. 19 to coincide with the European Cancer Organization meeting.

More information

The U.S. National Institute on Aging has more on hormones and menopause.

SOURCE: The Lancet, news release, Sept. 19, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com